Vice President, Vector Operations - Innovative Gene Therapy Start Up

Menlo Park, California, United States · Technical Operations


Location: Foster City, California

Reporting to: Chief Manufacturing Officer

This an exciting opportunity for a well-qualified candidate to join a rapidly growing international company focused on transforming the lives of patients with rare disorders through innovative gene therapies.

Orchard Therapeutics, Ltd. (OTL) is looking for a Vice President, Vector Operations to lead the global development, manufacture and delivery of lentiviral vectors to support the company’s product pipeline. Such activities will include building and leading the team responsible for development, scale-up, validation and execution of lentiviral vector manufacturing processes and controls to support OTL’s programs from pre-clinical studies through to product commercialization.


1. Build and lead the OTL team responsible for all aspects of the development, GMP production, fill finish and testing of lentiviral vectors for OTL’s pipeline

2. Ensure the ongoing security of the supply chain for raw materials and intermediates to assure the uninterrupted performance of lentiviral production operations and provision of material for pre-clinical, clinical and commercial programs

3. Identify and enable new technologies and operational modalities to optimize vector operations and improve productivity/yield and/or reduce cost of goods

4. Prepare and maintain departmental budgets

5. Provide senior management representation and liaison with Contract Manufacturing Organizations (CMOs), partners and in-house departments to ensure the successful achievement of company timelines and milestones

6. Implement effective contract lifecycle management and effective benchmarking methods to manage CMOs and external contract services/partners

7. Collaborate with senior management, CMOs and partners to define regulatory strategies and deliver required submission packages

8. Other activities as may be assigned


Job Requirements

The candidate for this position must have:

Education & skills


Platinum Healthcare Coverage, Dental and Vision, 401 (k) Safe Harbor Plan, Life Insurance and more including competitive Salary, Bonus and Equity scheme (role dependent).

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