Vice President, Cold Chain Supply Operations - Innovative Gene Therapy Start Up

London, England, United Kingdom · Supply Chain


Location: London, UK

Reporting to: Senior Vice President, Cell Therapy Operations

This an exciting opportunity for a well-qualified candidate to join a rapidly growing international company focused on transforming the lives of patients with rare disorders through innovative gene therapies.

Orchard Therapeutics, Ltd. (OTL) is looking for a Vice President to lead the implementation and execution of Cold Chain Supply Operations to support commercialization of OTL’s products. Such activities will include the design and implementation of integrated processes and procedures for the coordinated accession, manufacture, storage and distribution of OTL’s cryopreserved autologous, hematopoietic stem cell-based gene therapy products.



  1. Design and implement processes and procedures to ensure effective and compliant clinical and commercial supply chains
  2. Lead coordination with OTL’s Technical Operations, Clinical and Commercial Departments to Schedule:
    1. The harvest, packaging and collection of each patient’s bone marrow or peripheral blood at the designated hospitals/clinical centers for delivery to the designated manufacturing facility
    2. The manufacture and release of each autologous, gene therapy product at the designated manufacturing facility
    3. The packaging, collection and on time delivery of the autologous, gene therapy product from the manufacturing facility to the designated hospital/clinical center for the scheduled patient administration
    4. The administration of the autologous, gene therapy product to the patient at the designated hospital/clinical center
  1. Identify vendors then execute and administer service agreements/contracts for the:
    1. Packaging, collection, tracking and cold chain delivery of autologous bone marrow and peripheral blood product harvests from the designated hospitals/clinical centers to the designated manufacturing sites
    2. Packaging, collection, tracking and shipment of cryopreserved autologous, hematopoietic stem cell-based gene therapy products from the manufacturing site back to the hospital/clinical center for administration into the patient
  2. Ensure all required Import/Export documentation is available
  3. In collaboration with Quality Assurance and other relevant departments, lead the investigation, reporting and closure of deviations and associated CAPAs
  4. Develop Key Performance Indicators for supply chain activities, trend data and provide recommendations for improvements and cost reduction to senior management

7. Other activities as may be assigned

Job Requirements

The ideal candidate for this position must have

Extensive of experience in clinical and commercial supply chain management

Proven track record of supply chain planning, materials/inventory management, and business process facilitation, including:

Cell and gene therapy product experience a plus

In-depth knowledge of import and export requirements for countries in which OTL’s products are commercialized/distributed

In-depth knowledge of FDA, EMA, GMP, GCP and ICH regulatory requirements

Education & skills

BS degree or equivalent in a scientific discipline

Proven personnel and project management skills

Outstanding organizational skills

Excellent written and oral communication skills

Ability to operate in a fast-paced, multi-disciplinary industrial environment

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